The multimodality treatment has notably increased local control over locally advanced rectal cancer, with an exceptional oncologic efficacy and paid down regional recurrence rate from 35% to lower than 10%, and the proportion of patients receiving “watch and wait” strategy or delaying surgery increased as well. But, remote relapse continues to be the key reason behind cancer-related demise without improved long-term survival results. To improve therapy compliance and general success advantages, a novel method that delivered upfront chemotherapy prior to surgery, which is termed total neoadjuvant therapy (TNT), has been proposed. TNT has actually two significant patterns, including induction and consolidation therapy; the previous treatment structure calls for systemic chemotherapy before neoadjuvant chemoradiotherapy, while combination treatment refers to additional rounds of chemotherapy between neoadjuvant chemoradiotherapy and surgery. As a radiosensitizer, upfront chemotherapy not merely lowers gross tumefaction volume, but targets occult micro-metastatic infection at an early on phase. Several clinical trials also have stated that TNT achieves better regional control of condition with a promising therapy conformity. And organ preservation rate is meant to improve with a better pathologic or medical total response price. Besides, there existed no established opinion regarding to certain patterns and chemotherapy regimens and amounts, which results in remarkable distinctions among scientific studies. In conclusion, the exact oncologic efficacy and success advantages of total neoadjuvant therapy still need medical trials to confirm.Objective to research the safety and medical effectiveness of osteotomy after halo pelvic grip in serious scoliosis accompanied with split cord malformation. Methods The medical information of 14 clients with extreme scoliosis accompanied with split cable malformation admitted to the division of Spinal Surgical treatment, Guizhou Orthopedic Hospital from August 2015 to August 2019 had been retrospectively analyzed.There were 6 men and 8 females, aged (19.8±5.0) many years (range13 to 34 many years). All patients got vertebral orthopedic surgery after halo pelvic traction for 3 to 7 weeks.The data of traction time, height, Cobb position in the primary curved coronal plane and sagittal airplane, lung function and health condition regarding the patient were collected before and after the therapy. Paired t test ended up being made use of to compare the analysis indexes. Results The grip time of the 14 clients was (35.2±8.3)days (range20 to 49 days), as well as the height of them enhanced from (156.7±7.6)cm (range141 to 166 cm) before traction to (167.0±6.4)cm (rang±6.5) °, showing no statistically considerable distinction from the perspective after traction(t=0.16,P=0.88; t=2.28,P=0.32). There was no lack of orthopedic direction. None regarding the patients had inner fixation displacement, loosening or fracture. Conclusion The treatment of severe scoliosis with associated with split cord malformation by halo pelvic grip is secure and efficient, which can be worth additional confirmation by huge sample study.Objective To examine the long-term efficacy of radiofrequency closure in the remedy for great saphenous vein varicose. Techniques The center data of 185 patients with varicose veins of reduced limbs addressed with radiofrequency closure admitted at Department of Vascular operation, Beijing Shijitan Hospital, Capital health University from July 2016 to January 2017 ended up being analyzed retrospectively. An overall total of 203 limbs were treated by radiofrequency closure. The long-lasting effectiveness of radiofrequency closing ended up being examined by analyzing the closing rate, clinical-etiology- anatomy-pathophysiology (CEAP) grading, venous medical severity score (VCSS), chronic venous insufficiency survey (CIVIQ) score, and complications, using repeated actions analysis of variance. Results All treatments had been successful. The closing rate had been 98.0% (199/203) at twelve months and two years postoperative, which was however preserved at 97.5% (198/203) at 3 years of followup. Postoperative CEAP grading was significantly downgraded compared with that prior to the procedure. Totally 88.4% (76/86) of C5 to C6 quality clients downgraded to C2 to C4 level at half a year, and 95.3per cent (82/86) downgraded to C0 to C2 garde at three years postoperative. VCSS and CIVIQ score in both teams dramatically improved at all follow-up time points compared to preoperative scores (VCSS F=1 064.7, P=0.003; CIVIQ score F=2 984.3, P=0.001). The most frequent problem was subcutaneous bloodstream stasis (10.8%), nearly all of which disappeared within 1 month after the surgery. Various other complications included coloration and thrombophlebitis (5.9% and 3.9%, correspondingly). Conclusion The long-lasting efficacy of radiofrequency closing associated with great saphenous vein is satisfactory.Objective To evaluate the performance associated with European Evidence-based instructions on Pancreatic Cystic Neoplasms (EEGPCN)(2018) and Global Association of Pancreatology(IAP) Guideline(Version 2017) in predicting high grade dysplasia/invasive carcinoma-intraductal papillary mucinous neoplasm(HGD/INV-IPMN). Methods A retrospective analysis of 363 customers,who underwent surgical resection in Changhai Hospital affiliated to Navy healthcare University from January 2012 to December 2018 and had been pathologically recognized as (intraductal papillary mucinous neoplasm, IPMN),was performed. The customers,including 230 men and 133 females,aging (61.7±10.1) years(range19 to 83 many years). The proportion of HGD/INV-IPMN which met Eprenetapopt because of the absolute indication(AI) of EEGPCN and high risk stigma(HRS) of IAP were contrasted. The binary Logistic regression analysis had been used to find the independent danger aspects of HGD/INV-IPMN.Eight combinations of risk elements produced from general indication/worrisome feature or risk facets in thisly. Older patients and more youthful patients could correspondingly relate to combination Ⅶ and combo Ⅵ to improve TLC bioautography the management of IPMN. Conclusions clients molecular mediator who meet AI of EEGPCN should undertake resection, otherwise the technique we explored is recommended. The method of enhancement for diagnosis of HGD/INV-IPMN is relatively relevant and efficient for decision-making of surgery, specifically for more youthful patients with lowering of missed analysis and elder patients with decreasing of misdiagnosis.Objective to research the etiology,clinical functions and prognosis of pediatric liver retransplantation. Techniques the info of 1 024 instances of pediatric liver transplantation (30 days) team.